p53 mutations have been known to occur frequently in human cancers, but there have been only a few reports about p53 mutations in gallbladder cancer. Authors observed overexpression of p53 proteins, and investigated the clinical and pathologic
features
in 12 patients of the gallbladder carcinoma. Immunohistochemical staning for p53 proteins was doe by antihuman monoclonal antibody(Pab 1801; pharmingen, CA), and p53 overexpression was found in 75%(nine cases) of 12 resected specimens. When 9
cases
of
p53 overexpression according to extent of involvement were classified, 5 cases belonged to mild ones, 1 case to moderate and 3 cases to severe. And when they were classified according to intensity, 3 cases belonged to mild ones, 2 cases to
moderate
and
4 cases to severe. Probably invasion depth of tumor and extent of differentiation were not related with p53 overexpression. Further study will be necessary why gallbladder carcinoma has higher positivity for p53 proteins.
|